Application of DNA chip techniques for Yq microdeletion analysis in infertile males
نویسندگان
چکیده
منابع مشابه
The frequency of Yq microdeletion in azoospermic and oligospermic Iranian infertile men
BACKGROUND About 15% of couples have infertility problems which 40% of them are related to the male factors. Genetic factors are candidate for about 10% of male infertility conditions. Among these, AZFa, AZFb, AZFc and AZFd regions on the Yq are considered most important for spermatogenesis. Microdeletions of these regions are thought to be involved in some cases of azoospermic or oligospermic ...
متن کاملA new case of Yq microdeletion transmitted from a normal father to two infertile sons.
During the last few years, microdeletions of the long arm of the Y chromosome, involving loci AZFa, AZFb, and AZFc, have been identified as a major cause of infertility, leading to the disruption of genes involved in spermatogenesis. These microdeletions are usually de novo mutations, but in six cases transmission from fertile fathers to infertile sons has been reported. In four cases, the tran...
متن کاملChromosomal Abnormalities in Iranian Infertile Males who are Candidates for Assisted Reproductive Techniques
Background The present study offers our contribution on the topic by a retrospective analysis of the prevalence of chromosomal abnormalities in a population of Iranian infertile men attending assisted reproduction programs. MaterialsAndMethods Cytogenetic analysis was performed according to standard methods on cultured cells obtained from the patient peripheral blood. In all, 874 files belongin...
متن کاملHigher frequency of Yq microdeletions in sperm DNA as compared to DNA isolated from blood.
AIM To determine if Yq microdeletion frequency and loci of deletion are similar in two tissues (blood and sperm) of different embryological origin. METHODS The present study included 52 infertile oligozoospermic cases. In each case, DNA was isolated from blood and sperms and polymerase chain reaction (PCR) microdeletion analysis was done from genomic DNA isolated from both the tissues. The PC...
متن کاملthe frequency of yq microdeletion in azoospermic and oligospermic iranian infertile men
background: about 15% of couples have infertility problems which 40% of them are related to the male factors. genetic factors are candidate for about 10% of male infertility conditions. among these, azfa, azfb, azfc and azfd regions on the yq are considered most important for spermatogenesis. microdeletions of these regions are thought to be involved in some cases of azoospermic or oligospermic...
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ژورنال
عنوان ژورنال: Experimental & Molecular Medicine
سال: 2004
ISSN: 2092-6413
DOI: 10.1038/emm.2004.25